Expression of P-Glycoprotein in Hepatocellular Carcinoma

verapamil and rifampin effect on p-glycoprotein expression in hepatocellular carcinoma

conclusions verapamil and rifampin were found specific and effective against p-gp expression in hcc. in conclusion, treatment efficacy of most anticancer drugs is increased in combination with verapamil and rifampin against most advanced hcc. objectives the aim of this study was to elucidate the effect of potent carcinogen nitrosamine with and without verapamil and rifampin drugs on p-gp expres...

Expression of P-glycoprotein in hepatocellular carcinoma: a potential marker of prognosis.

AIMS (1) To investigate the immunohistochemical expression of the multidrug resistance gene (MDR1) product P-glycoprotein in histological samples from 31 hepatocellular carcinomas (HCCs); and (2) to correlate the results with cell proliferation, p53 expression, the disease-free interval, and cumulative patient survival. METHODS C219 (a monoclonal antibody), CM-1 (a polyclonal rabbit anti-huma...

P-glycoprotein expression affects 18F-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro.

18F-fluorodeoxyglucose (FDG) uptake in hepatocellular carcinoma (HCC) is associated with tumor differentiation and expression of P-glycoprotein (P-gp), a drug efflux pump that plays an important role in chemoresistance. The aim of the study was to clarify the factors that affects FDG uptake in HCC in vivo and in vitro. The standardized uptake value (SUV) and the tumor to non-tumor SUV ratio (TN...

Verapamil and Rifampin Effect on P-Glycoprotein Expression in Hepatocellular Carcinoma

BACKGROUND High expression of p-glycoprotein (P-gp) has been associated with a poor prognosis in patients with hepatocellular carcinoma (HCC). It is likely that P-gp overexpression is responsible for multidrug resistance in HCC. OBJECTIVES The aim of this study was to elucidate the effect of potent carcinogen nitrosamine with and without verapamil and rifampin drugs on P-gp expression at the ...

Hepatocellular Carcinoma in Sheep